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E20: Unlocking the Secrets of Genetics and Health With Jaclyn Downs

Photo of guest, Shannon Santerelli-Freeman
Host, Bethany Sadler-Jasmin, and guest, Jaclyn Downs

Unlocking the Secrets of Genetics and Health With Jaclyn Downs

I sit down with Jaclyn Downs, a Functional Genomics Analyst passionate about fertility and reproductive wellness, and the author of Enhancing Fertility through Functional Medicine. She explains how our genetic makeup influences our response to stress, anxiety, and overall health, and the importance of understanding genetic variants, the role of nutrition in gene expression, and the impact of oxidative stress on cellular health. Jaclyn breaks everything down in an easily understandable way and is so wonderful to talk with.


Guest: Jaclyn Downs

Instagram: ⁠@functionalgenomics


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SHOW NOTES

October 27th, 2025


keywords

genetics, nutrition, health, anxiety, oxidative stress, gut health, personalized nutrition, genetic variants, holistic health, functional genomics


summary

I sit down with Jaclyn Downs, a Functional Genomics Analyst passionate about fertility and reproductive wellness, and the author of Enhancing Fertility through Functional Medicine. She explains how our genetic makeup influences our response to stress, anxiety, and overall health, and the importance of understanding genetic variants, the role of nutrition in gene expression, and the impact of oxidative stress on cellular health. Jaclyn breaks everything down in an easily understandable way and is so wonderful to talk with.


takeaways

  • Genetics play a crucial role in how we handle stress and anxiety.

  • Nutrition serves as information for our genes, influencing their expression.

  • Oxidative stress is a significant factor in many chronic health issues.

  • Gut health is foundational for overall well-being and nutrient absorption.

  • Personalized nutrition based on genetic profiles can enhance health outcomes.

  • Stress can lead to cellular damage and affect immune function.

  • Understanding genetic variants can help tailor dietary and lifestyle choices.

  • Holistic approaches are essential for managing health effectively.

  • Foundational health practices benefit everyone, regardless of genetics.

  • Awareness of how lifestyle impacts genetic expression is vital for prevention.


Chapters

00:00

Introduction to Genetics and Health

02:56

The Role of Nutrition in Genetic Expression

05:42

Understanding Oxidative Stress and Its Impact

08:23

The Connection Between Stress and Nutrition

11:11

Personalized Genetic Interpretation

14:02

The Importance of Gut Health

16:44

Managing Anxiety Through Nutritional Insights

20:06

The Role of Supplements in Health

22:40

Proactive Health Management

25:30

Conclusion and Resources


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